FAQ - Flexiseq (Ireland)
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1. What is FLEXISEQ®?

2. What is the difference between FLEXISEQ® Osteoarthritis, and FLEXISEQ® Active?

3. Which FLEXISEQ® product should I choose?

4. Where can I purchase FLEXISEQ®?

5. How much does FLEXISEQ® cost?

6. What is the reason for the difference in price between FLEXISEQ® and FLEXISEQ® Active?

7. Can FLEXISEQ® products be prescribed by my doctor?

8. What is in the FLEXISEQ® products?

9. How well do the FLEXISEQ® products work?

10. What are the commonly reported side effects?

11. I have experienced a reaction to FLEXISEQ®; should I stop treatment?

12. How should I apply the gel?

13. What should I do if the product is applied incorrectly?

14. How often should I apply FLEXISEQ® products?

15. Can I alter treatment regimen to, say, every second day?

16. What are the differences between FLEXISEQ® and other pain treatments?

17. How well does FLEXISEQ® work compared with other topical products used for the same purpose?

18. How does FLEXISEQ® work?

19. What is the evidence that the Sequessome™ vesicles get into the joint?

20. Do all three products work in the same way?

21. How quickly does FLEXISEQ® work?

22. How long can I use FLEXISEQ® for?

23. What is the longest time that any patient has been treated for with FLEXISEQ®

24. How long does the pain relief last once treatment is stopped?

25. Are FLEXISEQ® products right for me?

26. Can FLEXISEQ® products be used in patients with other disorders such as MS, diabetes?

27. Can FLEXISEQ® be used alongside medications?

28. What is the total number of patients treated with FLEXISEQ®?

29. How have the safety and efficacy of FLEXISEQ® products been studied?

30. Why aren’t there any studies on the hands or other joints?

31. Is FLEXISEQ® as effective on other joints as it is on the knee?

32. Can FLEXISEQ® be used on joints other than the knee?

33. How should I store FLEXISEQ®?

34. I have not received any beneficial effect from these products – why?

35. Can I use body lotions, etc.?

36. Can FLEXISEQ® products be used in pregnancy or breastfeeding?

37. Is it available in all markets in Europe?

38. What is the regulatory status of FLEXISEQ®?

39. What company is marketing FLEXISEQ®?

40. Where is FLEXISEQ® manufactured?

41. Who should I report concerns or product issues to?

42. Please may I have the Summary of Product Characteristics for FLEXISEQ®?

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i Kneer W, Seidel EJ, Mazgareanu S, Rother M. J Pain Res 2013;6:743-753

ii Conaghan P, Dickson J, Bolten W, Cevc G, Rother M. Rheumatology 2013 Jul; 52(7):1303-12

iii Rother M, Conaghan PG. J Rheumatology 2013 2013;40:1742-48

iv NICE, 2008. Available at: www.nice.org.uk/CG059 (accessed 27 February 2012).

v McKenzie S, Torkington A. Aust Fam Physician 2010;39(9):622–625.

vi Coxib and Traditional NSAID Trialists’ (CNT) Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 2013;pii: Q5 S0140-6736(13)60900-9

vii Fosbøl EL, Gislason GH, Jacobsen S, et al. Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study. Clin Pharmacol Ther 2009;85:190-7

viii Hills BA, Monds MK. Br J Rheumatol 1998;37:143–147.

ix Vecchio P, Thomas R, Hills BA. Surfactant treatment for osteoarthritis. Rheumatology 1999;38:1020−1021

x Yurdakul S, Baverstock N, Mills J. Localisation of fluorescently labelled drug-free phospholipid vesicles to the cartilage surface of rat synovial joints. ICOOMD, London 2015

xi Clinical study report (sponsor code CL-033-III-05). IDEA AG, Frankfurter Ring 197a, 80807 Munich, Germany. 15 December 2008

xii Rother M, Yeoman G, Ekman E. Annual EULAR Congress 2012b Abstract no. EULAR12-3375

xiii National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), 2010. Osteoarthritis. Available at: www.niams.nih.gov/health_info/osteoarthritis/ (accessed 27 February 2012).

xiv Kneer W, et al. Curr Drug Saf 2009;4:5–10.